Developmental biology / Scott F. Gilbert.

Author
Edition
  • 9th ed.
Published
  • Sunderland, Mass. : Sinauer Associates ©2010
Physical description
xxi, 711, [80] pages : illustrations (chiefly color) ; 29 cm
ISBN
  • 9780878933846
  • 0878933840
  • 0878935649
  • 9780878935642
Notes
  • Previous ed.: c2006.
  • Includes bibliographical references and indexes.
Audience
  • Specialized.
Contents
  • Developmental anatomy -- Developmental genetics -- Cell-cell communication in development -- Fertilization -- Early development in selected invertebrates -- The genetics of axis specification in drosphila -- Amphibians and fish -- Birds and mammals -- The Emergence of the ectoderm -- Neural crest cells and axonal specificity -- Paraxial and intermediate mesoderm -- Lateral plate mesoderm and the endoderm -- Development of the tetrapod limb -- Sex determination -- Postembryonic development -- The saga of the germ line -- Medial aspects of developmental biology -- Developmental plasticity and symbiosis -- Developmental mechanisms of evolutionary change.
Related item
Genre
  • Bibliography
  • Illustrated
  • text
Language
  • English
Related Internet Resources
Contents
  • pt. I QUESTIONS Introducing Developmental Biology (starting p. 1) -- ch. 1 Developmental Anatomy (starting p. 5) -- The Cycle of Life (starting p. 6) -- A Frog's Life (starting p. 6) -- Gametogenesis and fertilization (starting p. 6) -- Cleavage and gastralation (starting p. 7) -- Organogenesis (starting p. 10) -- Metamorphosis and gametogenesis (starting p. 11) -- "How are You" (starting p. 12) -- Comparative embryology (starting p. 12) -- Epigenesis and preformation (starting p. 12) -- Naming the parts: The primary germ layers and early organs (starting p. 14) -- The four principles of Karl Ernst von Baer (starting p. 16) -- Keeping Track of Moving Cells: Fate Maps and Cell Lineages (starting p. 17) -- Fate maps (starting p. 19) -- Direct observation of living embryos (starting p. 19) -- Dye marking (starting p. 19) -- Genetic labeling (starting p. 20) -- Transgenic DNA chimeras (starting p. 22) -- Evolutionary Embryology (starting p. 23) -- Embryonic homologies (starting p. 24) -- Medical Embryology and Teratology (starting p. 27) -- Genetic malformations and syndromes (starting p. 27) -- Disruptions and teratogens (starting p. 28) -- ch. 2 Developmental Genetics (starting p. 31) -- Evidence for Genomic Equivalence (starting p. 32) -- Sidelights & Speculations The Basic Tools of Developmental Genetics (starting p. 32) -- Differential Gene Transcription (starting p. 35) -- Anatomy of the gene: Active and repressed chromatin (starting p. 36) -- Anatomy of the gene: Exons and introns (starting p. 37) -- Anatomy of the gene: Promoters and enhancers (starting p. 39) -- Transcription factor function (starting p. 42) -- Sidelights & Speculations Reprogramming Cells: Changing Cell Differentiation through Embryonic Transcription Factors (starting p. 45) -- DNA Methylation and the Control of Transcription (starting p. 48) -- Mechanisms by which DNA methylation blocks transcription (starting p. 49) -- Inheritance and stabilization of DNA methylation patterns (starting p. 49) -- Sidelights & Speculations Consequences of DNA Methylation (starting p. 50) -- Differential RNA Processing (starting p. 53) -- Control of early development by nuclear RNA selection (starting p. 53) -- Creating families of proteins through differential nRNA splicing (starting p. 54) -- Splicing enhancers and recognition factors (starting p. 56) -- Control of Gene Expression at the Level of Translation (starting p. 58) -- Differential mRNA longevity (starting p. 58) -- Selective inhibition of mRNA translation: Stored oocyte mRNAs (starting p. 58) -- microRNAs: Specific regulators of mRNA translation and transcription (starting p. 61) -- Sidelights & Speculations microRNAs in Transcriptional Gene Regulation (starting p. 63) -- Control of RNA expression by cytoplasmic localization (starting p. 64) -- Stored mRNAs in brain cells (starting p. 65) -- Posttranslational regulation of gene expression (starting p. 66) -- ch. 3 Cell-Cell Communication in Development (starting p. 69) -- Cell Adhesion (starting p. 70) -- Differential cell affinity (starting p. 70) -- The thermodynamic model of cell interactions (starting p. 72) -- Cadherins and cell adhesion (starting p. 73) -- Sidelights & Speculations Shape Change and Epithelial Morphogenesis: "The Force is Strong in You" (starting p. 76) -- Cell Migration (starting p. 78) -- Cell Signaling (starting p. 79) -- Induction and competence (starting p. 79) -- Cascades of induction: Reciprocal and sequential inductive events (starting p. 80) -- Instructive and permissive interactions (starting p. 81) -- Epithelial-mesenchymal interactions (starting p. 82) -- Paracrine Factors: The Inducer Molecules (starting p. 84) -- Signal transduction cascades: The response to inducers (starting p. 85) -- Fibroblast growth factors and the RTK pathway (starting p. 85) -- The JAK-STAT pathway (starting p. 88) -- The Hedgehog family (starting p. 90) -- The Wnt family (starting p. 92) -- The TGF-β superfamily (starting p. 94) -- Other paracrine factors (starting p. 95) -- Sidelights & Speculations Cell Death Pathways (starting p. 96) -- Juxtacrine Signaling (starting p. 98) -- The Notch pathway: Juxtaposed ligands and receptors (starting p. 98) -- Sidelights & Speculations Juxtacrine Signaling and Cell Patterning (starting p. 99) -- Maintaining the Differentiated State (starting p. 101) -- The Extracellular Matrix as a Source of Developmental Signals (starting p. 102) -- Integrins: Receptors for extracellular matrix molecules (starting p. 102) -- Epithelial-Mesenchymal Transition (starting p. 105) -- pt. II SPECIFICATION Introducing Cell Commitment and Early Embryonic Development (starting p. 109) -- Levels of Commitment (starting p. 109) -- Autonomous Specification (starting p. 110) -- Conditional Specification (starting p. 112) -- Morphogen Gradients and Cell Specification (starting p. 116) -- Syncytial Specification (starting p. 117) -- Summary (starting p. 119) -- ch. 4 Fertilization: Beginning a New Organism (starting p. 121) -- Structure of the Gametes (starting p. 121) -- Sperm (starting p. 121) -- The egg (starting p. 125) -- Recognition of egg and sperm (starting p. 127) -- External Fertilization in Sea Urchins (starting p. 127) -- Sperm attraction: Action at a distance (starting p. 128) -- The acrosome reaction (starting p. 130) -- Recognition of the egg's extracellular coat (starting p. 131) -- Fusion of the egg and sperm cell membranes (starting p. 133) -- The fast block to polyspermy (starting p. 135) -- The slow block to polyspermy (starting p. 136) -- Calcium as the initiator of the cortical granule reaction (starting p. 137) -- Activation of Egg Metabolism in Sea Urchins (starting p. 139) -- Release of intracellular calcium ions (starting p. 139) -- Effects of calcium (starting p. 142) -- Sidelights & Speculations Rules of Evidence: "Find It, Lose It, Move It" (starting p. 144) -- Fusion of genetic material (starting p. 145) -- Internal Fertilization in Mammals (starting p. 145) -- Getting the gametes into the oviduct: Translocation and capacitation (starting p. 145) -- In the vicinity of the oocyte: Hyperactivation, thermotaxis, and chemotaxis (starting p. 148) -- Recognition at the zona pellucida (starting p. 149) -- Gamete fusion and the prevention of polyspermy (starting p. 152) -- Fusion of genetic material (starting p. 153) -- Sidelights & Speculations The Nonequivalence of Mammalian Pronuclei (starting p. 154) -- Activation of the mammalian egg (starting p. 155) -- Coda (starting p. 155) -- ch. 5 Early Development in Selected Invertebrates (starting p. 159) -- Early Developmental Processes: An Overview (starting p. 159) -- Cleavage (starting p. 159) -- From fertilization to cleavage (starting p. 160) -- The cytoskeletal mechanisms of mitosis (starting p. 161) -- Patterns of embryonic cleavage (starting p. 162) -- Gastrulation (starting p. 162) -- Cell Specification and Axis Formation (starting p. 164) -- Early Development in sea Urchins (starting p. 165) -- Sea urchin Cleavage (starting p. 165) -- Blastula formation (starting p. 166) -- Fate maps and the determination of sea urchin blastomeres (starting p. 166) -- Global regulatory networks and skeletogenic mesenchyme specification (starting p. 167) -- Specification of the vegetal cells (starting p. 171) -- Axis specification (starting p. 172) -- Sea Urchin Gastrulation (starting p. 172) -- Ingression of the skeletogenic mesenchyme (starting p. 172) -- Invagination of the archenteron (starting p. 176) -- Early Development in Snails (starting p. 178) -- Cleavage in Snail Embryos (starting p. 178) -- The snail fate map (starting p. 181) -- The polar lobe: Cell determination and axis formation (starting p.

Summary

  • Increased emphasis on gene activity, signal transduction and the emphasis on the roles of paracrine factors in development. This undergraduate textbook synthesizes the organismal, cellular, and evolutionary aspects of animal development. The seventh edition adds a chapter on the medical implications of developmental biology. The CD-ROM contains 140 videos and 300 labeled photographs that walk through the life cycle of model organisms. Annotation (c)2003 Book News, Inc., Portland, OR.

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