An Introduction to Pharmaceutical Sciences : Production, Chemistry, Techniques and Technology.

Author
Published
  • Cambridge : Elsevier Science 2011
Physical description
1 online resource (449 pages)
ISBN
  • 9781908818041
  • 9781907568527
Notes
  • Description based on publisher supplied metadata and other sources.
Contents
  • Cover -- Woodhead Publishing Series in Biomedicine -- An introduction to pharmaceutical sciences: Production, chemistry, techniques and technology -- Copyright -- Dedication -- Contents -- Preface -- Why this book? -- What materials are covered? -- Future editions -- Acknowledgements -- List of figures and tables -- Abbreviations -- About the author -- 1 Introduction -- Learning objective -- 1.1 The theme of the book -- 1.2 Development of the pharmaceutical industry and its impact -- 1.3 Important milestones in the introduction of pharmaceuticals -- 1.4 The multidisciplinary nature of pharmaceutical sciences -- 1.5 Medicinal trees -- 1.6 Pharmaceutical research and development -- 1.7 Pharmaceutical technology -- 1.8 Pharmaceutical economics -- 1.9 The world pharmaceutical market -- 1.10 Embedded ethics in the pharmaceutical industry -- Notes -- 2 Career prospects in the pharmaceutical industry -- Learning objective -- 2.1 Job opportunities in the pharmaceutical industry -- 2.2 Education and training -- 2.3 Various departments of a pharmaceutical company -- 2.4 Mergers and acquisitions in the pharmaceutical industry -- 2.5 Careers for pharmaceutical physicians -- Notes -- 3 Drugs, medicines, and regulatory authorities -- Learning objective -- 3.1 Drugs and medicines: brand names and generic names -- 3.2 Drug names -- 3.3 Drug discovery and the drug development process -- 3.4 Marketing of generic drugs in the USA or Europe -- 3.5 The role of pharmacopoeias -- 3.6 Regulatory agencies -- Notes -- 4 Bulk drugs or active pharmaceutical ingredients -- Learning objective -- 4.1 Bulk drugs and bulk drug plants -- 4.2 Lab to manufacturing level scale-up -- 4.3 Bulk drug manufacturing -- 4.4 Solubility of API -- 4.5 Stereoisomeric bulk drugs -- 4.6 Stability, degradation, and impurity profiles of bulk drugs.
  • 4.7 Drug development, scale up, and analytical development -- 4.8 Green chemistry in bulk drug manufacturing -- Notes -- 5 Formulated drugs 1 -- Learning objective -- 5.1 Introduction -- 5.2 The role of excipients -- 5.3 The classification of dosage forms -- 5.4 Formulation and manufacturing of tablets -- 5.5 Problems with tablet manufacturing and the use of process analytical technology -- 5.6 Liquid dosage forms -- 5.7 Production of oral solution and suspension dosage forms -- 5.8 Dosage forms in pediatrics -- Notes -- 6 Formulated drugs 2 -- Learning objective -- 6.1 Dosage forms according to route of administration -- 6.2 The parenteral route of administration -- 6.3 The pulmonary route of administration -- Note -- 7 The stability of medicines -- Learning objective -- 7.1 Stability - an essential criterion of medicines -- 7.2 Label instructions and stability of medicines at home -- 7.3 Drug stability kinetics -- 7.4 Stabilization of pharmaceutical products -- 7.5 The International Conference on Harmonization -- 7.6 Product stability protocol -- 7.7 Packaging and stability of medicines -- Notes -- 8 Quality assurance in medicines -- Learning objective -- 8.1 The concept of quality assurance -- 8.2 Evolution of quality testing and safety of medicine -- 8.3 Quality management systems -- 8.4 Good manufacturing practice in sterile production -- 8.5 Validation -- 8.6 Contamination control in formulation factory -- 8.7 Limits of good quality -- Notes -- 9 Pharmacological concepts and drugs -- Learning objective -- 9.1 Drug action -- 9.2 Routes of drug administration -- 9.3 Mechanism of oral medication -- 9.4 Drug absorption, bioavailability, and activity -- 9.5 Pharmacokinetic profile of oral and IV dosage forms -- 9.6 Metabolism, or biotransformation of drugs -- 9.7 Bioavailability, bioequivalence, and generic drugs.
  • 9.8 Safety and the toxic effects of drugs -- 9.9 The ideal pharmacokinetics and pharmacodynamics of a drug -- Notes -- 10 The top five most common or long-selling drugs -- Learning objective -- 10.1 Amoxicillin - the largest-selling β-lactam antibiotic -- 10.2 Aspirin - the longest-selling drug on the market -- 10.3 Paracetemol - the best-selling antipyretic analgesic in the world -- 10.4 Ranitidine - the world's leading prescribed drug Key concept terms -- 10.5 Ciprofloxacin - the best-selling antibacterial in the world -- Notes -- 11 Life-style drugs, statins, and COX-2 drugs -- Learning objective -- 11.1 An introduction to sildenafil citrate (Viagra) -- 11.2 Discovery of sildenafil citrate -- 11.3 Synthesis of sildenafil citrate -- 11.4 How does sildenafil work in the body? -- 11.5 Dosage form of sildenafil citrate -- 11.6 Atorvastatin - a brief introduction -- 11.7 Discovery of atorvastatin -- 11.8 Synthesis of atorvastatin calcium -- 11.9 Stereochemistry and atorvastatin -- 11.10 Mechanism of action of atorvastatin -- 11.11 Dosage forms of atorvastatin -- 11.12 Celecoxib and rofecoxib -- 11.13 The mechanism of COX-2 inhibition by celecoxib and rofecoxib -- 11.14 Metabolism and cardiotoxicity of celecoxib and rofecoxib -- Notes -- 12 Counterfeit drugs and drug abuse -- Learning objective -- 12.1 Counterfeit drugs -- 12.2 Anticounterfeiting strategies -- 12.3 Risks of internet pharmacies -- 12.4 Drug abuse -- Notes -- 13 New pharmaceutical technology and pharmaceuticals -- Learning objective -- 13.1 Biologics -- 13.2 Nanomedicines by nanotechnology -- 13.3 Regenerative medicines -- 13.4 Transdermal patch technology -- Notes -- 14 Future prospects for the pharmaceutical industry -- Learning objective -- 14.1 Introduction -- 14.2 Carbon and silicon -- 14.3 The role of the pharmaceutical industry in increasing longevity -- 14.4 Aspirin to Avastin.
  • 14.5 Monoclonal antibody drugs -- 14.6 The future shape of the pharmaceutical industry -- 14.7 Personalized medicine -- 14.8 Treatment of the increasing ageing population -- 14.9 Controlled-release drugs using a magnetic field switch -- 14.10 The world pharmaceutical market and employment -- 14.11 Stronger generics markets in future -- 14.12 Generic biologics and biosimilars market potential -- 14.13 Emerging new markets -- 14.14 Biotechnology - a way forward -- 14.15 Stem cell therapy - hope for the future -- 14.16 Technology and automation -- 14.17 The future pharmaceutical R&D work force -- Notes -- 15 Pharmaceutical case studies -- Learning objective -- 15.1 Medicines given to an 11-year-old girl following adenoidectomy and tonsillectomy -- 15.2 Drug-food interactions -- 15.3 Effervescent tablets -- Notes -- Index.
Related item
Genre
  • Electronic books.
  • text
Language
  • English

Summary

  • This textbook is written as a unified approach to various topics, ranging from drug discovery to manufacturing, techniques and technology, regulation and marketing. The key theme of the book is pharmaceuticals - what every student of pharmaceutical sciences should know: from the active pharmaceutical ingredients to the preparation of various dosage forms along with the relevant chemistry, this book makes pharmaceuticals relevant to undergraduate students of pharmacy and pharmaceutical sciences.This book explains how a particular drug was discovered and then converted from lab-scale to manufacturing scale, to the market. It explains the motivation for drug discovery, the reaction chemistry involved, experimental difficulties, various dosage forms and the reasoning behind them, mechanism of action, quality assurance and role of regulatory agencies. After having a course based on this book, the student will be able to understand: 1) the career prospects in the pharmaceutical industry, 2) the need for interdisciplinary teamwork in science, 3) the techniques and technology involved in making pharmaceuticals starting from bulk drugs, and 4) different dosage forms and critical factors in the development of pharmaceutical formulations in relation to the principles of chemistry.A few blockbuster drugs including atorvastatin, sildanefil, ranitidine, ciprofloxacin, amoxicillin, and the longest serving drugs such as aspirin and paracetamol are discussed in detail. Finally, the book also covers the important current pharmaceutical issues like quality control, safety, counterfeiting and abuse of drugs, and future prospects for pharmaceutical industry.Unified approach explaining drug discovery, bulk drug manufacturing, formulation of dosage forms, with pharmacological and therapeutic actionsManufacturing processes of representative active pharmaceutical
  • ingredients and their chemistry plus formulation of dosage forms presented in this book are based on actual industrial processesCovers many aspects relevant to students of the pharmaceutical sciences or newly employed pharmaceutical researchers/employees. It contains summary information about regulatory agencies of different countries.

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